TY - JOUR AU - Phumlek, Kalyarut AU - Itharat, Arunporn AU - Lee, Hyang-Yeol AU - Pongcharoen, Padcha AU - Moon, Gi-Seong AU - Chakkavittumrong, Panlop AU - Davies, Neal M. PY - 2022/08/01 Y2 - 2024/03/29 TI - Hydrogel Patch Containing Mangosteen Ethanolic Extract and Its Clinical Safety for Acne Vulgaris Treatment JF - Asian Medical Journal and Alternative Medicine JA - AMJAM VL - 22 IS - - SE - Abstracts DO - 10.14456/2022s10743 UR - https://asianmedjam.com/index.php/amjam/article/view/1324 SP - S136 AB - <p><strong>Introduction:</strong> <em>Garcinia mangostana</em>, simply known as mangosteen, has long been used as Thai traditional medicine because it was reported antibacterial and anti-inflammatory activities for skin infection treatment. <br /><strong>Objectives:</strong> This study aims to develop mangosteen pericarps into a hydrogel patch against acne-inducing bacteria and evaluate its clinical safety.<br /><strong>Methods:</strong> The hydrogel patch containing mangosteen ethanolic extract was investigated for antibacterial activity against <em>Cutibacterium acnes</em>, <em>Staphylococcus epidermidis</em>, and <em>Staphylococcus </em><em>aureus</em>. Its mechanical properties, <em>in vitro</em> release, skin permeation, and phase I clinical study of skin irritation and allergic testing by closed patch test were also investigated.<br /><strong>Results:</strong> The mangosteen hydrogel patch made from carrageenan and locust bean gum powders was a yellow patch that is smooth, durable, and flexible. This patch was effectively against <em>Cutibacterium acnes</em>, <em>Staphylococcus epidermidis</em>, and <em>Staphylococcus aureus</em>. The active ingredient, α-mangostin, was released and permeated from the mangosteen hydrogel patch within the first 30 min at 33.16% and 32.96%, respectively. Mangosteen ethanolic extract and hydrogel patch showed no irritation in 30 healthy volunteers. However, two volunteers (6.67%) had delayed allergic contact dermatitis to 2-5% mangosteen ethanolic extract and 0.5% (w/w) mangosteen hydrogel patch. <br /><strong>Conclusions:</strong> This hydrogel patch containing mangosteen ethanolic extract could be considered as an anti-acne facial mask. Nevertheless, it is not recommended for people who have any reaction to mangosteen.</p> ER -