Unusual Morphologic Features of Small Duct Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation

Authors

  • Sasathorn Taeudomkul Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand
  • Malisa Surapatpichai Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand
  • Charinee Kantasiripitak Division of Pathology, Thammasat University Hospital, Pathumthani, Thailand
  • Thiyaphat Laohawetwanit Chulabhorn International College of Medicine, Thammasat University and Division of Pathology, Thammasat University Hospital, Pathum Thani, Thailand

Keywords:

Ductal plate malformation, Intrahepatic cholangiocarcinoma, Combined hepatocellular-cholangiocarcinoma

Abstract

We present a case of small duct intrahepatic cholangiocarcinoma with a ductal plate malformation (iCCA with DPM) showing unusual pathologic features. iCCA with DPM is an uncommon subtype of small duct iCCA. This uncommon neoplasm has unique clinicopathological characteristics. Pathological evaluation is necessary for diagnosing correctly.

Downloads

Download data is not yet available.

References

Banales JM, Marin JJG, Lamarca A, et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol. 2020;17(9):557-588.

Paradis V, Fukayama M, Park Y, Schirmacher P. Tumours of the liver and intrahepatic bile ducts. In: WHO classification of tumours editorial board. WHO classification of tumours-digestive system tumours. 5th ed. Lyon: IARC; 2019:215-264.

Nakanuma Y, Sato Y, Ikeda H, et al. Intrahepatic cholangiocarcinoma with predominant “ductal plate malformation” pattern: a new subtype. Am J Surg Pathol. 2012;36(11):1629-1635.

Wang Q, Xu Y, Wang SM, Hu AY, Pan YC, Zhang SH. Histopathological evidence of intrahepatic cholangiocarcinoma occurring in ductal plate malformation: A clinicopathologic study of 5 cases. Ann Diagn Pathol. 2021;55:151828.

Chung T, Rhee H, Shim HS, et al. Genetic, Clinicopathological, and Radiological Features of Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation Pattern. Gut Liver. 2021.

Sasaki M, Sato Y, Nakanuma Y. Cholangiolocellular Carcinoma With “Ductal Plate Malformation” Pattern May Be Characterized by ARID1A Genetic Alterations. Am J Surg Pathol. 2019;43(3):352-360.

Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S. Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology. Ann Diagn Pathol. 2021;53:151770.

Brunt E, Aishima S, Clavien PA, et al. cHCCCCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. Hepatology. 2018;68(1):113-126.

Downloads

Published

2023-04-27

How to Cite

[1]
Taeudomkul , S. , Surapatpichai, M. , Kantasiripitak , C. and Laohawetwanit, T. 2023. Unusual Morphologic Features of Small Duct Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation. Asian Medical Journal and Alternative Medicine. 23, 1 (Apr. 2023), 81–85.

Issue

Section

Case Report