Efficacy of Zingiber cassumunar Roxb (Phlai capsule) Compare with Loratadine as Treatment in Allergic Rhinitis Patients (Preliminary Results)

Authors

  • Patrada Thanee Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
  • Ratchaya Lertnawapan Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Internal medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
  • Paskorn Sritipsukho Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
  • Sira Nanthapisal Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
  • Prapasri Kulalert Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Pediatrics, Faculty of Medicine, Thammasat University, P
  • Pattara Tanticharoenwiwat Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
  • Nitchanan Achararit Center of Excellent for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathum Thani, Thailand and Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, T
  • Pongsakorn Tantilipikorn Siriraj Clinical Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand and Department of Otolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Tha
  • Orapan Poachanukoon Thammasat University

DOI:

https://doi.org/10.14456/2022s10101

Keywords:

Zingiber cassumunar , Phlai, Allergic rhinitis, Antihistamine, Quality of life

Abstract

Introduction: Phlai capsules can inhibit skin reactivity in allergic rhinitis patients.
Objectives: The aim of this study was to compare the efficacy of Phlai capsules with Loratadine in allergic rhinitis patients.
Methods: This was a multi-center, prospective, randomized, double-blinded, placebo-controlled study in 50 patients, aged 18-50 years old, who randomly received 4 mg or 8 mg Phlai capsules or Loratadine for 8 weeks. The primary efficacy endpoint was Total Symptoms Score at 4 and 8 weeks. The secondary endpoints were peak nasal inspiratory flow and quality of life.
Results: Demographic data was similar between groups. The change in 6-Total symptoms score decreased significantly from baseline. Peak nasal inspiratory flow increased with no significant differences between groups. According to the RCQ-36 questionnaire, there wassignificant improvement in quality of life for every domain, including sleep and emotion.
Conclusions: Phlai capsules reduced rhinitis symptoms and improved quality of life.

 

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The 6-total symptoms score at baseline, 4 and 8 weeks.

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Published

2022-08-01

How to Cite

[1]
Thanee, P., Lertnawapan, R., Sritipsukho, P., Nanthapisal, S., Kulalert, P., Tanticharoenwiwat, P., Achararit, N., Tantilipikorn, P. and Poachanukoon, O. 2022. Efficacy of Zingiber cassumunar Roxb (Phlai capsule) Compare with Loratadine as Treatment in Allergic Rhinitis Patients (Preliminary Results). Asian Medical Journal and Alternative Medicine. 22, - (Aug. 2022), S15-S21. DOI:https://doi.org/10.14456/2022s10101.

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Original Articles