Daily Consumption of Monosodium Glutamate Pronounced Hypertension and Altered Renal Excretory Function in Normotensive and Hypertensive Rats
Keywords:Monosodium glutamate, Hypertension, Renal function, 2K1C
Introduction: It has been reported that monosodium glutamate (MSG) administration induces oxidative stress and affects various human physiologic functions.
Objectives: This study aims to investigate the effects of MSG on levels of arterial blood pressure (ABP) and renal excretory function.
Methods: Male Wistar rats were divided into 2 groups (n = 24 each), namely, sham operation (SO) and 2-kidneys-1-clip (2K1C) to develop the normotensive and hypertensive models, respectively. Four weeks after the operation, each group of rats was further divided into 4 subgroups (n = 6 each) which were orally administered either distilled water or MSG at the doses of 80, 160, or 320 mg/kg BW/day once a day for 8 weeks. The body weight, the 24-hour water intake, and the 24-hour urine output were recorded weekly. Then, each rat was anesthetized and the ABP was measured via carotid artery. The renal excretory function was examined by using the clearance markers containing 1% inulin and 1% para-amino hippuric acid (PAH) via jugular vein infusion. Blood samples collected from carotid artery and urine samples collected from bladder, were used to measure the levels of inulin and PAH. Renal clearances of inulin and PAH represent the glomerular filtration rate and the renal blood flow, respectively. The levels of serum malondialdehyde as a marker of oxidative stress were also analyzed.
Results: It was found that all doses of MSG significantly increased the mean arterial pressure in both SO and 2K1C groups. Long-term intake of 320 mg/kg BW MSG significantly decreased the renal excretion of salt and water in both SO and 2K1C groups.
Conclusions: This study demonstrated that MSG consumption contributed to the increase of oxidative stress which could lead to alterations in the cardiovascular and renal function.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.