The Utility of Preoperative CT Scans for the Differentiation of Mucinous versus Non-mucinous Colorectal Adenocarcinoma
Keywords:Colorectal CA, Computed tomography (CT), Mucinous adenocarcinoma, Non-mucinous adenocarcinoma, Preoperative evaluation
Objectives: To assess the characteristics of mucinous versus non-mucinous colorectal
adenocarcinoma by preoperative computed tomography (CT) scans.
Methods: A retrospective study was conducted over a 12-year, 6-month period for a
comparative assessment of preoperative abdominal CT scans in 143 participants
postoperatively confirmed with either mucinous (47 participants) or non-
mucinous colorectal adenocarcinoma (96 participants). Two experienced
abdominal radiologists separately conducted a blinded review of preoperative CT
scans for tumor characterization. A stratified comparative analysis was
Results: The mean tumor diameter and length were significantly greater in the mucinous
group (p-value < 0.001). The presence of heterogeneous enhancement and an area
of hypoattenuation greater than two-thirds of the tumor volume were more
frequently visualized in the mucinous group (p-value = 0.001 and p-value <
0.001, respectively). Tumor characterization as a heterogeneous enhancement
plus an area of hypoattenuation more than two-thirds of the tumor volume had
diagnostic utility for mucinous adenocarcinoma with a sensitivity, specificity, and
accuracy of 66.0%, 95.8%, and 86.0%, respectively.
Conclusions: Preoperative CT scans have potential for differentiation of mucinous versus non-
mucinous colorectal adenocarcinoma.
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