The Utility of Preoperative CT Scans for the Differentiation of Mucinous versus Non-mucinous Colorectal Adenocarcinoma


  • Piyaporn Apisarnthanarak
  • Sirudcha Polsak
  • Voraparee Suvannarerg
  • Vilasinee Rerkpichaisuth
  • Kobkun Muangsomboon
  • Wanwarang Teerasamit
  • Sopa Pongpornsup
  • Anucha Apisarnthanarak


Colorectal CA, Computed tomography (CT), Mucinous adenocarcinoma, Non-mucinous adenocarcinoma, Preoperative evaluation


Objectives:     To assess the characteristics of mucinous versus non-mucinous colorectal

                        adenocarcinoma by preoperative computed tomography (CT) scans.

Methods:        A retrospective study was conducted over a 12-year, 6-month period for a  

                        comparative assessment of preoperative abdominal CT scans in 143 participants    

                        postoperatively confirmed with either mucinous (47 participants) or non-

                        mucinous colorectal adenocarcinoma (96 participants). Two experienced

                        abdominal radiologists separately conducted a blinded review of preoperative CT

                        scans for tumor characterization. A stratified comparative analysis was 


Results:          The mean tumor diameter and length were significantly greater in the mucinous

                        group (p-value < 0.001). The presence of heterogeneous enhancement and an area

                        of hypoattenuation greater than two-thirds of the tumor volume were more

                        frequently visualized in the mucinous group (p-value = 0.001 and p-value <

                        0.001, respectively). Tumor characterization as a heterogeneous enhancement

                        plus an area of hypoattenuation more than two-thirds of the tumor volume had

                        diagnostic utility for mucinous adenocarcinoma with a sensitivity, specificity, and

                        accuracy of 66.0%, 95.8%, and 86.0%, respectively.

Conclusions:  Preoperative CT scans have potential for differentiation of mucinous versus non-

                        mucinous colorectal adenocarcinoma.


Download data is not yet available.


Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system, 4th ed. Lyon: IARC Press; 2010.

Park JS, Huh JW, Park YA, et al. Prognostic comparison between mucinous and nonmucinous adenocarcinoma in colorectal cancer. Medicine (Baltimore). 2015;94:e658.

Verhulst J, Ferdinande L, Demetter P. Ceelen W. Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis. J Clin Pathol. 2012;65:381-388.

Consorti F, Lorenzotti A, Midiri G, Di Paola M. Prognostic significance of mucinous carcinoma of colon and rectum: a prospective case-control study. J Surg Oncol. 2000;73:70-74.

Hussain SM, Outwater EK, Siegelman ES. Mucinous versus nonmucinous rectal carcinomas: differentiation with MR imaging. Radiology. 1999;213:79-85.

Kim MJ, Park JS, Park SI, et al. Accuracy in differentiation of mucinous and nonmucinous rectal carcinoma on MR imaging. J Comput Assist Tomogr. 2003;27:48-55.

Ko EY, Ha HK, Kim AY, et al. CT differentiation of mucinous and nonmucinous colorectal carcinoma. Am J Roentgenol. 2007;188:785-791.

Liu Y, Dou Y, Lu F, Liu L. A study of radiomics parameters from dual-energy computed tomography images for lymph node metastasis evaluation in colorectal mucinous adenocarcinoma. Medicine (Baltimore). 2020;99:e19251.




How to Cite

Apisarnthanarak, P., Polsak, S., Suvannarerg, V., Rerkpichaisuth, V., Muangsomboon, K., Teerasamit, W., Pongpornsup, S. and Apisarnthanarak, A. 2023. The Utility of Preoperative CT Scans for the Differentiation of Mucinous versus Non-mucinous Colorectal Adenocarcinoma. Asian Medical Journal and Alternative Medicine. 23, 2 (Aug. 2023), 129–138.



Original Articles