Potential Thai Herbal Medicine for COVID-19

Authors

  • Arunporn Itharat Department of Applied Thai Traditional Medicine and Center of Excellence in Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Vilailak Tiyao Center of Excellence on Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Kodchanipha Sutthibut Center of Excellence on Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Neal M. Davies Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada

Keywords:

SARS-CoV-2, COVID19, Thai herbs, Mechanism of action

Abstract

     SARS-CoV-2 is a cause of COVID-19 a contagious respiratory disease, in which there are many signs and symptoms such as fever, dry cough, shortness of breath, muscle ache, and pneumonia. Meanwhile, antiviral drug mechanisms which are being used to treat SARS-CoV-2 with Western drugs can be divided into three groups as follows: increasing acidic conditions by endosomal formation; viral replication; and affinity interaction with ACE-2 receptor via S-protein. Therefore, hydroxychloroquine/chloroquine, lopinavir, remdesivir, favipiravir, and molnupiravir which have been utilized to treat HIV and influenza via inhibiting viral replication and alkalinization could also modulate COVID-19 symptoms. However, antiviral drugs also have limited use in hospitalized and severe COVID-19 cases. The objective of this review is to provide a comprehensive analysis of Thai Herbal Medicine findings suggesting antiviral property potential that natural compounds derived from Thai plants could be further developed or provide mechanistic understanding of current drug treatment of COVID-19. Cinchona bark constituents create an alkaline environment to reduce viral replication and perfusion in cells. Certain medicinal plants which possess antiviral replication and blockage of the affinity binding between S-protein of SARS-CoV-2 and ACE2 receptor include Andrographis paniculata, Boesenbergia rotunda, Zingiber officinale, Phyllanthus amarus, Phylanthus emblica, Glycyrrhiza glabra, and Citrus medica. These plants were summarized for their potential in COVID-19 treatment. Integrating Thai Traditional Medicine principles with contemporary COVID-19 treatment mechanisms would certainly have valuable provide more efficient clinical therapy.

Author Biographies

Vilailak Tiyao, Center of Excellence on Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand

She help to review COVID19 characteristic and Mechanism

Rank No 2

Center of Excellence on Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani, 12120, Thailand

Kodchanipha Sutthibut, Center of Excellence on Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand

Rank No3

She help to review Thai Traditional medicine.

she is postdocteral in Center of Excellence on Thai Traditional Medicine

Neal M. Davies, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada

Rank no 4

 He prove our English and help to write discussion.

He is Professorship of Bualuang

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Published

2021-10-29

How to Cite

[1]
Itharat, A., Tiyao, V., Sutthibut, K. and Davies, N.M. 2021. Potential Thai Herbal Medicine for COVID-19. Asian Medical Journal and Alternative Medicine. 21, - (Oct. 2021), S58-S73.