COVID-19 Associated Coagulopathy: Inflammation and Coagulation Linkage


  • Lantarima Bhoopat Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand


COVID-19 associated coagulopathy (CAC), Vascular thrombosis, Cytokine storm, Endotheliopathy


The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) infection, which causes coronavirus disease (COVID-19), has become a worldwide pandemic since emerging in December 2019. The severity of the disease ranges from asymptomatic carriers to severe manifestations, such as acute respiratory distress syndrome (ARDS) and multiorgan failure. The proposed etiology for severe disease and death were micro- and macro-vascular thromboses, which are major components of COVID-19 associated coagulopathy (CAC). CAC is associated with cytokine storm, causing inflammation, endothelial injury, and subsequent thrombosis. Heparin is useful in this circumstance because of many proposed mechanisms. Multiple studies have reported the benefit of heparin in decreasing mortality in critically ill patients. However, the optimal dose and duration are yet to be determined.




How to Cite

Bhoopat, L. 2021. COVID-19 Associated Coagulopathy: Inflammation and Coagulation Linkage. Asian Medical Journal and Alternative Medicine. 21, - (Oct. 2021), S102-S107.